Promethazine hydrochloride and codeine phosphate syrup is indicated for that short-term aid of coughs and higher respiratory indications associated with allergy or perhaps the common chilly.
If you think There have been an overdose, simply call your poison Command center or get professional medical care right away. Be willing to explain to or show what was taken, simply how much, and when it took place. How can I store and/or throw out Promethazine and Codeine?
To assist protect against withdrawal, your health care provider may possibly reduced your dose slowly and gradually. Withdrawal is more most likely In case you have used this medication for a long period (quite a lot of months) or in substantial doses. Convey to your medical professional or pharmacist without delay For those who have withdrawal.
Do not forget that this medication continues to be prescribed mainly because your doctor has judged the benefit for you is greater than the risk of Negative effects. Many of us using this medication do not need major Unintended effects.
Remedy of overdosage is pushed by the overall scientific presentation, and contains discontinuation of Promethazine with Codeine Oral Solution collectively with institution of ideal therapy. Give Main interest into the reestablishment of enough respiratory exchange by way of provision of a patent and guarded airway and the establishment of assisted or controlled air flow.
No evidence of tumorigenicity was observed in male and feminine mice at codeine dietary doses approximately four hundred mg/kg/working day (close to comparable to forty four situations the MRHD with a mg/m two basis). Codeine wasn't mutagenic from the in vitro bacterial reverse mutation assay or clastogenic from the in vitro Chinese hamster ovary (CHO) cell chromosomal aberration assay. Fertility reports with codeine have not been conducted.
A probably lethal symptom sophisticated occasionally called Neuroleptic Malignant Syndrome (NMS) has long been described in association with promethazine HCl by itself or in combination with antipsychotic medicines.
Promethazine with Codeine Oral Solution really should be utilized with caution in clients with severe impairment of renal operate, and people ought to be monitored closely for respiratory despair, sedation, and hypotension.
Codeine in oral therapeutic dosage will not commonly exert big consequences over the cardiovascular procedure.
Tend not to enhance your dose or use this solution much more often or for longer than prescribed. Your ailment will not likely strengthen any more quickly, and your hazard of Unintended effects will raise.
Promethazine with Codeine Oral Answer is contraindicated get more info for all young children young than twelve many years of age [see Contraindications ( 4) ]. Promethazine with Codeine Oral Resolution is contraindicated for write-up-operative administration in pediatric individuals more youthful than 18 yrs of age next tonsillectomy and/or adenoidectomy [see Contraindications ( four) ]. Steer clear of the use of Promethazine with Codeine Oral Remedy in adolescents twelve to 18 a long time of age who have other chance things which will increase their sensitivity towards the respiratory depressant results of codeine Except if the benefits outweigh the hazards.
Administration of codeine could be accompanied by histamine release and may be applied with caution in atopic kids.
Impaired secretion from sweat glands next toxic doses of medicines with anticholinergic Unwanted side effects may well predispose to hyperthermia.
Extended use of opioids in the course of pregnancy may perhaps result in neonatal opioid withdrawal syndrome [see Warnings and Safety measures ( five.19) and Scientific Factors]. There won't be any available info with Promethazine with Codeine Oral Option use in Expecting Ladies to inform a drug-affiliated risk for adverse developmental outcomes. Revealed scientific tests with codeine have claimed inconsistent findings and have crucial methodological constraints (see Facts). There are reviews of respiratory melancholy when codeine is utilised through labor and supply (see Scientific Considerations). Reproductive toxicity research have not been conducted with Promethazine with Codeine Oral Answer; nonetheless, reports can be obtained with particular person Energetic elements (see Knowledge).